GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs3213758 | 1 | rs1078620 | chr16:53664597 | RPGRIP1L | chr16:53633823-53737771:- | -0.22 | -3.56 | 0.00039 | Vitiligo (non-segmental) |
| BRCA | cis | rs11190604 | 1 | rs10786596 | chr10:102282126 | SEC31B | chr10:102246403-102289636:- | -0.29 | -10.93 | 2.05E-26 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11190604 | 1 | rs10786597 | chr10:102291287 | SEC31B | chr10:102246403-102289636:- | -0.3 | -11.09 | 3.91E-27 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs11190604 | 1 | rs10786598 | chr10:102291579 | SEC31B | chr10:102246403-102289636:- | -0.3 | -11.09 | 3.91E-27 | Palmitoleic acid (16:1n-7) plasma levels |
| BRCA | cis | rs1056667 | 1 | rs1078679 | chr6:26568741 | BTN2A3 | chr6:26422317-26431927:+ | 0.16 | 5.42 | 7.27E-8 | Educational attainment |
| BRCA | cis | rs1056667 | 1 | rs1078679 | chr6:26568741 | C6orf41 | chr6:26924772-26991752:+ | -0.13 | -3.94 | 8.81E-5 | Educational attainment |
| BRCA | cis | rs1056667 | 1 | rs1078679 | chr6:26568741 | ZNF322A | chr6:26634612-26659963:- | -0.11 | -3.73 | 0.000201 | Educational attainment |
| BRCA | cis | rs10788473 | 1 | rs10788473 | chr10:87740753 | WAPAL | chr10:88195014-88281541:- | 0.09 | 3.47 | 0.000544 | Pancreatic cancer |
| BRCA | cis | rs1867631 | 1 | rs10789212 | chr1:67128155 | TCTEX1D1 | chr1:67218140-67244729:+ | 0.12 | 3.39 | 0.000732 | Menopause (age at onset) |
| BRCA | cis | rs1867631 | 1 | rs10789213 | chr1:67128201 | TCTEX1D1 | chr1:67218140-67244729:+ | 0.12 | 3.43 | 0.000621 | Menopause (age at onset) |
| BRCA | cis | rs2275426 | 1 | rs10789475 | chr1:46304177 | CCDC163P | chr1:45960581-45965646:- | -0.38 | -11.47 | 8.61E-29 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10789475 | chr1:46304177 | MUTYH | chr1:45794915-45806142:- | 0.12 | 4.93 | 9.34E-7 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10789481 | chr1:46383583 | CCDC163P | chr1:45960581-45965646:- | -0.41 | -11.99 | 3.58E-31 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10789481 | chr1:46383583 | MUTYH | chr1:45794915-45806142:- | 0.13 | 4.9 | 1.11E-6 | Body mass index |
| BRCA | cis | rs2275426 | 1 | rs10789487 | chr1:46420221 | CCDC163P | chr1:45960581-45965646:- | -0.4 | -11.9 | 9.15E-31 | Body mass index |